Selection and testing of a rigid, aromatic ligand for binding Gadolinium (III)
Technical Report
·
OSTI ID:10135895
Paramagnetic compounds are under widespread study as contrast agents in magnetic resonance imaging. These agents increase contrast in magnetic resonance imaging by increasing the relaxation rates of nearby water protons. This report describes a strategy of designing paramagnetic contrast agents with high stability for the paramagnetic metal ion gadolinium(III), low toxicity in vivo, high relativity, and the ability to be covalently attached to antibodies for targeted delivery. Computer modeling of porphyrin analog ligands for gadolinium(III) were used to select sapphyrins for further study. The Gd({sup 3+}) sapphyrins were synthesized and their physical properties were characterized.
- Research Organization:
- Los Alamos National Lab., NM (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 10135895
- Report Number(s):
- LA--12531-MS; ON: DE93008908
- Country of Publication:
- United States
- Language:
- English
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