Effect of lithosperm on thyroidal /sup 32/P uptake at various times of injection

Journal Article · Wed Jun 01 00:00:00 EDT 1983 · Contraception; (United States)

DOI:https://doi.org/10.1016/0010-7824(83)90028-8· OSTI ID:6658595

Breneman, W R; Zeller, F J

These experiments were performed to increase our understanding of possible side effects in the use of extracts of the plant Lithospermum ruderale (LSPM) as a contraceptive. Cold-water extracts of LSPM were used to note possible effects on injected TSH and on endogenous TSH which was increased by the use of propylthiouracil. It was demonstrated that LSPM had a biphasic effect on both endogenous and exogenous TSH activity as measured by chick thyroid /sup 32/P uptake. When given 18h before autopsy, LSPM decreased TSH activity in both, whereas when LSPM was administered 42h or 44h before autopsy, TSH activity was significantly increased.

• OSTI ID: 6658595
• Journal Information: Contraception; (United States), Journal Name: Contraception; (United States) Vol. 27:6; ISSN CCPTA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUGMENTATION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIRDS
BODY
CHICKENS
DAYS LIVING RADIOISOTOPES
DRUGS
ENDOCRINE GLANDS
FOWL
GLANDS
HORMONES
INHIBITION
INJECTION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
MATERIALS
MEDICINAL PLANTS
NUCLEI
ODD-ODD NUCLEI
ORGANS
PEPTIDE HORMONES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PITUITARY HORMONES
PLANTS
RADIOISOTOPES
REACTION KINETICS
REPRODUCTION
SIDE EFFECTS
THYROID
TIME DEPENDENCE
TISSUE EXTRACTS
TRACER TECHNIQUES
TSH
UPTAKE
VERTEBRATES