Kinetics of the human thyroid trap: effects of iodide, thyrotropin, and propylthiouracil. [Technetium-99, adults]

Journal Article · Sat Sep 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5824952

Hays, M T

Effects on the thyroidal pertechnetate trap of iodide, thyrotropin (TSH), and propylthiouracil (PTU), compared with duplicated control studies, were assessed in normal subjects using i.v. (/sup 99m/TC) pertechnetate, a multicrystal scintillation camera, and a compartmental model. Sodium iodide administered orally on two occasions, 2 wk apart, caused an early drop in plasma clearance into the follicular cell with later return to normal clearance 1 wk after the second NaI dose. In this later study, exit from the colloid was elevated. Plasma equivalent volume of the colloid compartment was reduced in both postiodine studies. Thyrotropin, 10 units intramuscularly, was followed by no significant changes in trap parameters at 2 hr. At 24 hr, plasma clearance had doubled and the plasma equivalent colloid volume had tripled. Propylthiouracil was given as a single 1 g dose 1 hr before a trapping study, followed by 200 mg PTU every 8 hr for 1 wk. The first dose resulted in apparent reduction in all of the rate constants for transport across the basal and apical thyroid follicular cell membranes; these rates returned toward control levels after 1 wk. The plasma equivalent follicular cell volume was reduced to 66% of control levels after 1 wk PTU. These effects must be taken into account in the interpretation of studies of the trap based on PTU pretreatment to inhibit organification.

• Research Organization: Veterans Administration Central Office, Washington, DC
• OSTI ID: 5824952
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
ALKALI METAL COMPOUNDS
ANTITHYROID DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BODY
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DRUGS
ENDOCRINE GLANDS
EXPERIMENTAL DATA
GLANDS
HALIDES
HALOGEN COMPOUNDS
HORMONES
HOURS LIVING RADIOISOTOPES
INFORMATION
INORGANIC PHOSPHORS
INTERMEDIATE MASS NUCLEI
IODIDES
IODINE COMPOUNDS
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PERTECHNETATES
PHOSPHORS
PITUITARY HORMONES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTISCANNING
SODIUM COMPOUNDS
SODIUM IODIDES
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
THYROID
TRANSITION ELEMENT COMPOUNDS
TSH
YEARS LIVING RADIOISOTOPES