In-vivo effect of Lithospermum ruderale on LHRH activity in the chick
Lithospermum (LSPM) plant extracts can inhibit gonadotropin action in mammals and birds. The experiments reported in this paper were performed to note the possible effect of LSPM on the ability of LHRH to stimulate /sup 32/P testis uptake in immature chicks. LHRH injected 2 h before autopsy significantly increased /sup 32/P uptake in these animals. Water extracts of Lithospermum ruderale roots were administered subcutaneously at various concentrations and times before LHRH. LSPM injections of 2.0, 4.0, or 8.0 mg equivalents of dried material given 10 h before LHRH significantly suppressed the releasing hormone effect. 4.0 mg LSPM was not inhibitory at 16, 22, 38 or 46 h before LHRH. Interestingly, LHRH had a greater effect, as measured by /sup 32/P testis uptake, when given to these latter 3 groups then when given to controls. This suggests that LSPM may have prevented the release but not the synthesis of anterior pituitary gonadotropins.
- OSTI ID:
- 5311025
- Journal Information:
- Contraception; (United States), Journal Name: Contraception; (United States) Vol. 24:1; ISSN CCPTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BIRDS
BODY
CHICKENS
DAYS LIVING RADIOISOTOPES
DRUGS
FOWL
GONADOTROPINS
GONADS
HORMONES
IN VIVO
INHIBITION
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MALE GENITALS
MEDICINAL PLANTS
NUCLEI
ODD-ODD NUCLEI
ORGANS
PEPTIDE HORMONES
PHARMACOLOGY
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PITUITARY HORMONES
PLANTS
RADIOISOTOPES
REPRODUCTION
SYNTHESIS
TESTES
UPTAKE
VERTEBRATES