Chromium (VI) potentiates mutagenesis by sodium azide but not ethyl methanesulfonate
Journal Article
·
· Environ. Mutagen.; (United States)
A fluctuation test using Salmonella typhimurium strain 1535 has been used in an experimental protocol to assess biological effects of interactions between chromium (VI), such as K/sub 2/CrO/sub 4/, and two DNA-damaging agents, ethyl methanesulfonate (EMS), and sodium azide. For the combination of K/sub 2/CrO/sub 4/ and NaN/sub 3/, the response was significantly greater than expected suggesting a possible potentiation of mutagenesis. The opposite (a less-than-additive response) was found for the K/sub 2/CrO/sub 4//EMS combination. Both effects were found to be dose related to the concentration of potassium chromate used. Toxicity of the compounds or their combinations to the bacterial could not explain the results.
- Research Organization:
- Thomas Jefferson Univ., Philadelphia, PA
- OSTI ID:
- 6658281
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 6:3; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
AZIDES
BACTERIA
BIOLOGICAL EFFECTS
CHROMATES
CHROMIUM COMPOUNDS
DNA
EMS
ESTERS
GENETIC EFFECTS
MICROORGANISMS
MUTAGENS
MUTATIONS
NITROGEN COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
POTASSIUM COMPOUNDS
SALMONELLA
SALMONELLA TYPHIMURIUM
SODIUM COMPOUNDS
SULFONIC ACID ESTERS
SYNERGISM
TRANSITION ELEMENT COMPOUNDS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
AZIDES
BACTERIA
BIOLOGICAL EFFECTS
CHROMATES
CHROMIUM COMPOUNDS
DNA
EMS
ESTERS
GENETIC EFFECTS
MICROORGANISMS
MUTAGENS
MUTATIONS
NITROGEN COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
POTASSIUM COMPOUNDS
SALMONELLA
SALMONELLA TYPHIMURIUM
SODIUM COMPOUNDS
SULFONIC ACID ESTERS
SYNERGISM
TRANSITION ELEMENT COMPOUNDS