Role of DNA repair in ethyl methanesulfonate-induced mutagenesis in Saccharomyces cerevisiae
Journal Article
·
· Carcinogenesis (N.Y.); (United States)
Ethyl methanesulfonate (EMS)-induced reversion of two sites which revert preferentially by GC to AT transitions, cycl-131 and cycl-115, has been examined in readiation sensitive, rad, mutants of yeast belonging to the rad52 epistasis group. The rad50, rad 51, rad52, rad54 and rad56 mutants showed reduced reversion of both tester sites when stationary phase diploid cells were treated with EMS. No correlation was found between EMS-induced reversion and EMS-induced homologous mitotic intragenic recombination. Survival of rad6 rad52 double mutants following EMS treatment indicates that there is one epistasis group for the repair of EMS-induced lethal damage in yeast. A model involving misrepair mutagenesis of specific lesions is proposed to account for the experimental results.
- Research Organization:
- Rochester Univ., NY
- OSTI ID:
- 6328812
- Journal Information:
- Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 3:4; ISSN CRNGD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
COMPARATIVE EVALUATIONS
DNA
ELECTROMAGNETIC RADIATION
EMS
ESTERS
FUNGI
GENE MUTATIONS
GENE RECOMBINATION
GENES
GENETIC EFFECTS
METABOLISM
MICROORGANISMS
MUTAGENESIS
MUTAGENS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PLANTS
QUANTITY RATIO
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
STRUCTURAL CHEMICAL ANALYSIS
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
YEASTS
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
COMPARATIVE EVALUATIONS
DNA
ELECTROMAGNETIC RADIATION
EMS
ESTERS
FUNGI
GENE MUTATIONS
GENE RECOMBINATION
GENES
GENETIC EFFECTS
METABOLISM
MICROORGANISMS
MUTAGENESIS
MUTAGENS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PLANTS
QUANTITY RATIO
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
STRUCTURAL CHEMICAL ANALYSIS
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
YEASTS