Phospholipid and glyceride biosynthesis in 2,4,5,2',4',5'-hexachlorobiphenyl-treated human skin fibroblasts
Journal Article
·
· Environ. Res.; (United States)
2,4,5,2',4',5'-Hexachlorobiphenyl (HCB) was taken up by cultured human skin fibroblasts (A61437; GM488). HCB caused enhanced incorporation of (2-/sup 14/C)acetate into phospholipids and glycerides at low concentration and reduced incorporation at high concentrations. sn-(U-/sup 14/C)Glycerol-3-phosphate incorporation into phospholipids was inhibited. No significant change in total cellular phospholipids was observed. Triglyceride cellular content was increased 29%. The observed stimulation and inhibition of phosphoglyceride synthesis are similar to results obtained with rat liver microsomes.
- Research Organization:
- Oregon State Univ., Corvallis
- OSTI ID:
- 6656989
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
Similar Records
2,4,5,2',4',5'-Hexachlorobiphenyl-lipoprotein (LDL, HDL, VLDL) interaction and induced lipidosis in cultured skin fibroblasts
Differences in ( sup 14 C)glycerol utilization in normal and familial hypercholesterolemic fibroblasts
Distribution and excretion of 2,3,6,2',3',6'- and 2,4,5,2',4',5'-hexachlorobiphenyl in senescent rats
Journal Article
·
Fri Jun 01 00:00:00 EDT 1984
· Environ. Res.; (United States)
·
OSTI ID:6678132
Differences in ( sup 14 C)glycerol utilization in normal and familial hypercholesterolemic fibroblasts
Journal Article
·
Mon Dec 31 23:00:00 EST 1990
· Artery (Fulton, Michigan); (USA)
·
OSTI ID:5642819
Distribution and excretion of 2,3,6,2',3',6'- and 2,4,5,2',4',5'-hexachlorobiphenyl in senescent rats
Journal Article
·
Thu Sep 15 00:00:00 EDT 1983
· Toxicol. Appl. Pharmacol.; (United States)
·
OSTI ID:6962620
Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AROMATICS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARBON 14 COMPOUNDS
CELL CULTURES
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE CELLS
ESTERS
FIBROBLASTS
HALOGENATED AROMATIC HYDROCARBONS
KINETICS
LABELLED COMPOUNDS
LIPIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
REACTION KINETICS
SKIN
SOMATIC CELLS
SYNTHESIS
TRIGLYCERIDES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AROMATICS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARBON 14 COMPOUNDS
CELL CULTURES
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE CELLS
ESTERS
FIBROBLASTS
HALOGENATED AROMATIC HYDROCARBONS
KINETICS
LABELLED COMPOUNDS
LIPIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
REACTION KINETICS
SKIN
SOMATIC CELLS
SYNTHESIS
TRIGLYCERIDES