2,4,5,2',4',5'-Hexachlorobiphenyl-lipoprotein (LDL, HDL, VLDL) interaction and induced lipidosis in cultured skin fibroblasts
Journal Article
·
· Environ. Res.; (United States)
2,4,5,2',4',5'-Hexachlorobiphenyl (HCB) induced cytoplasmic inclusions and lipidosis in normal (AG1437) and hypercholesterolemic (GM488) human skin fibroblasts. Quantitative and qualitative microscopic fluorescence analysis showed that the cytoplasmic inclusions are formed as early as 3 hr after treatment with HCB. The inclusions contain lipids but no detectable nonesterified cholesterol or cholesteryl ester. High density lipoproteins (HDL), low density lipoproteins (LDL), and very low density lipoproteins (VLDL) facilitate the apparent uptake of HCB by skin fibroblasts. HDL and LDL appeared to reverse the induction of cytoplasmic inclusions and lipidosis when cells were pretreated with HCB, the HCB was removed from media, and the cells were incubated with LDL or HDL. The results suggest that lipoproteins participate in the uptake and egress of HCB from skin fibroblasts.
- Research Organization:
- Oregon State Univ., Corvallis
- OSTI ID:
- 6678132
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CELL CULTURES
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE CELLS
FIBROBLASTS
HALOGENATED AROMATIC HYDROCARBONS
KINETICS
LIPIDS
LIPOPROTEINS
MAMMALS
MAN
MEMBRANE TRANSPORT
MORPHOLOGICAL CHANGES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PRIMATES
PROTEINS
REACTION KINETICS
SKIN
SOMATIC CELLS
ULTRASTRUCTURAL CHANGES
UPTAKE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CELL CULTURES
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE CELLS
FIBROBLASTS
HALOGENATED AROMATIC HYDROCARBONS
KINETICS
LIPIDS
LIPOPROTEINS
MAMMALS
MAN
MEMBRANE TRANSPORT
MORPHOLOGICAL CHANGES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PRIMATES
PROTEINS
REACTION KINETICS
SKIN
SOMATIC CELLS
ULTRASTRUCTURAL CHANGES
UPTAKE
VERTEBRATES