Effects of high-dose and low-dose preoperative irradiation on low anterior anastomoses in dogs

Journal Article · · Dis. Colon Rectum; (United States)

DOI:https://doi.org/10.1007/BF02553643· OSTI ID:6653383

Bubrick, M P; Rolfsmeyer, E S; Schauer, R M; Feeney, D A; Johnston, G R; Strom, R L; Hitchcock, C R

Twenty mongrel dogs underwent preoperative irradiation to the colon and rectum, receiving 4000 rads according to the Nominal Standard Dose Equation. Each dog then underwent anterior resection of the rectosigmoid, and reconstructive technique was randomized into two groups consisting of either handsewn or EEA-stapled anastomoses. Anastomoses were examined digitally and radiographically at the time of surgery and on the seventh postoperative day. There were four radiographic leaks among the handsewn anastomoses, but only one was clinically significant and associated with peritonitis. There were no leaks among the ten EEA-stapled anastomoses. The data suggest that low anterior resection and anastomosis can be done safely after 4000 rad irradiation and that the EEA-stapled anastomosis may be preferable.

• Research Organization: Departments of Surgery and Pathology, Hennepin County Medical Center, Minneapolis Medical Research Foundation, Minneapolis Minnesota
• OSTI ID: 6653383
• Journal Information: Dis. Colon Rectum; (United States), Journal Name: Dis. Colon Rectum; (United States) Vol. 25:5; ISSN DICRA
• Country of Publication: United States
• Language: English

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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
GASTROINTESTINAL TRACT
INTESTINES
LARGE INTESTINE
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
THERAPY
VERTEBRATES