Low anterior anastomotic dehiscence following preoperative irradiation with 6000 rads

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Dis. Colon Rectum; (United States)

DOI:https://doi.org/10.1007/BF02555669· OSTI ID:7133171

Blake, D P; Bubrick, M P; Kochsiek, G G; Feeney, D A; Johnston, G R; Strom, R L; Hitchcock, C R

Twenty mongrel dogs received 6000 rads of irradiation to the rectum and colon using the Nominal Standard Dosage Equation. Three weeks after irradiation each dog underwent anterior resection of the rectosigmoid with reconstruction randomized to either an EEA stapled or a two layer handsewn anastomosis. Each dog was studied digitally and by barium enema at the time of surgery, on the seventh postoperative day, and at autopsy. Five clinically significant leaks and three radiographic leaks occurred in the EEA stapled anastomoses. The handsewn anastomoses had five clinically significant leaks and two radiographic leaks. The data indicate that low anterior resection with either an EEA stapled or handsewn anastomosis cannot be done safely after 6000 rad preoperative irradiation.

• Research Organization: Department of Surgery, Hennepin County Medical Center, Minneapolis, MN
• OSTI ID: 7133171
• Journal Information: Dis. Colon Rectum; (United States), Journal Name: Dis. Colon Rectum; (United States) Vol. 27:3; ISSN DICRA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DOGS
DOSE-RESPONSE RELATIONSHIPS
EVALUATION
GASTROINTESTINAL TRACT
INJURIES
INTESTINES
LARGE INTESTINE
MAMMALS
MEDICINE
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RECTUM
SURGERY
VERTEBRATES