Assignment of the human carboxypeptidase E (CPE) gene to chromosome 4

Journal Article · Sun Jan 31 23:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1093· OSTI ID:6652779

Hall, C ^[1]; Manser, E ^[2]; Spurr, N K ^[3]; Lim, L ^[4]

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1. Inst. of Neurology, London (United Kingdom)
2. National Univ. of Singapore (Singapore)
3. Clare Hall Lab., Herts (United Kingdom)
4. Inst. of Neurology, London (United Kingdom) National Inst. of Singapore (Singapore)

We recently reported the characterization of a human and a rat brain cDNA-encoding carboxypeptidase E (CPE or carboxypeptidase H; EC 3.4.17.10) isolated during our screening for brain expressed genes. The human and rat CPEs share more than 95% protein sequence homology with bovine CPE. CPE is a processing enzyme that cleaves C-terminal amino acids and is implicated in biogenesis of neuropeptides and neurohormones, being enriched in brain and adrenal secretory granules. Human CPE is highly related to human carobxypeptidases N (51% identity) and M (43% identity), which occur in serum and ubiquitously in cell membranes, respectively. The functions of these other carboxypeptidases is not yet known. The less related carboxypeptidase A has been mapped to chromosome 7q (320ter) as has trypsin. We now report the localization of CPE to chromosome 4, to which other proteases also map as well as several genes of neurological interest.

• OSTI ID: 6652779
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 15:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
BODY
BRAIN
CARBOXYLIC ACIDS
CARBOXYPEPTIDASES
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
ENZYMES
GENES
GENETIC MAPPING
HORMONES
HUMAN CHROMOSOMES
HYDROLASES
MAPPING
MEMBRANES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PEPTIDES
PROCESSING
PROTEINS
SERINE PROTEINASES
TRYPSIN