Comparative effects of chelating drugs on trace metal and biochemical alterations in the rat
Chelation therapy is the most successful modality for the management of heavy metal poisoning. The success of these drugs stem from their multidentate polyfunctional chelating behavior. The therapeutic mechanism for chelating drugs involves their interaction with toxic metals leading to their rapid excretion from the body. However, because of their indiscriminate affinity for various metal ions, the potential interactions between these drugs and endogenous trace metals is of concern. It was, therefore, of importance to define new chelating drugs which in addition to being effective as an antidote in metal poisoning may possess low undesirable toxicity. In the present communication the authors compare the acute effect of Cyclam with those of other conventional chelating drugs namely, triethylenetetramine (TETA), reduced glutathione (GSH), ethylenediamine tetraacetic acid (EDTA), cyclohexanediamine tetraacetic acid (CDTA), diethylene triamine pentaacetic acid (DTPA) and hydroxyethylenediamine triacetic acid (HEDTA) on (i) serum levels of Cu, Zn, lactate dehydrogenase (LDH), glutamyloxaloacetic transaminase (GOT) and ceruloplasmin (CP); (ii) hepatic and renal levels of Cu, Mn, Zn and Fe and (iii) hepatic and renal levels of GSH, glutathione-S-transferase (GST) and phosphoglucomutase (PGM) at various time intervals (16, 24 and 72 hrs) after their administration to rats.
- Research Organization:
- Industrial Toxicology Research Centre, Lucknow (India)
- OSTI ID:
- 6648084
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 41:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHELATING AGENTS
BIOLOGICAL EFFECTS
METALS
BLOOD CHEMISTRY
BIOCHEMISTRY
CDTA
COPPER COMPOUNDS
DTPA
ENZYME ACTIVITY
GLUTATHIONE
HEDTA
IRON COMPOUNDS
KIDNEYS
LACTATE DEHYDROGENASE
MANGANESE COMPOUNDS
RATS
TETAHA
TRACE AMOUNTS
ZINC COMPOUNDS
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
CHEMISTRY
DRUGS
ELEMENTS
ENZYMES
HEMIACETAL DEHYDROGENASES
HYDROXY ACIDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology