Removal of nickel by chelating drugs from the organs of nickel poisoned rats
The chelating drugs namely ethylenediamine tetraacetic acid (EDTA), 1,2,cyclohexylenediamine tetraacetic acid (CDTA), hydroxyethylenediamine triacetic acid (HEDTA) diethylenetriamine pentaacetic acid (DTPA), and triethylenetetraamine hexaacetic acid (TTHA), were examined for the mobilization of nickel from body organs of sham operated and partially hepatectomized rats in early nickel poisoning. These chelating drugs successfully reduced the body burden of nickel from both the nickel treated experimental groups. EDTA was relatively more effective in reducing the hepatic content of nickel while CDTA and HEDTA were more effective in reducing its renal content. These drugs also reduced nickel burden in heart and lung to variable degrees.
- Research Organization:
- Industrial Toxicology Research Centre, Lucknow, India
- OSTI ID:
- 5321585
- Journal Information:
- Chemosphere; (United States), Vol. 15:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHELATING AGENTS
BIOLOGICAL EFFECTS
NICKEL COMPOUNDS
BODY BURDEN
CDTA
DECONTAMINATION
DTPA
EDTA
HEART
HEDTA
KIDNEYS
LIVER
LUNGS
RATS
TETAHA
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CLEANING
DIGESTIVE SYSTEM
DRUGS
GLANDS
HYDROXY ACIDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)