Removal of nickel by chelating drugs from the organs of nickel poisoned rats
Journal Article
·
· Chemosphere; (United States)
The chelating drugs namely ethylenediamine tetraacetic acid (EDTA), 1,2,cyclohexylenediamine tetraacetic acid (CDTA), hydroxyethylenediamine triacetic acid (HEDTA) diethylenetriamine pentaacetic acid (DTPA), and triethylenetetraamine hexaacetic acid (TTHA), were examined for the mobilization of nickel from body organs of sham operated and partially hepatectomized rats in early nickel poisoning. These chelating drugs successfully reduced the body burden of nickel from both the nickel treated experimental groups. EDTA was relatively more effective in reducing the hepatic content of nickel while CDTA and HEDTA were more effective in reducing its renal content. These drugs also reduced nickel burden in heart and lung to variable degrees.
- Research Organization:
- Industrial Toxicology Research Centre, Lucknow, India
- OSTI ID:
- 5321585
- Journal Information:
- Chemosphere; (United States), Journal Name: Chemosphere; (United States) Vol. 15:6; ISSN CMSHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY BURDEN
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CDTA
CHELATING AGENTS
CLEANING
DECONTAMINATION
DIGESTIVE SYSTEM
DRUGS
DTPA
EDTA
GLANDS
HEART
HEDTA
HYDROXY ACIDS
KIDNEYS
LIVER
LUNGS
MAMMALS
NICKEL COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPIRATORY SYSTEM
RODENTS
TETAHA
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY BURDEN
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CDTA
CHELATING AGENTS
CLEANING
DECONTAMINATION
DIGESTIVE SYSTEM
DRUGS
DTPA
EDTA
GLANDS
HEART
HEDTA
HYDROXY ACIDS
KIDNEYS
LIVER
LUNGS
MAMMALS
NICKEL COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPIRATORY SYSTEM
RODENTS
TETAHA
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES