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Chelation in metal intoxication XVI. Influence of chelating agents on chromate poisoned rats

Journal Article · · Chemosphere; (United States)
The ability of selective polyaminocarboxylic acids and common drugs to reduce the body burden of chromium and restore Cr induced biochemical alterations in chromate intoxicated rats was investigated. 1,2 Cychlohexylene dinitrilotetraacetic acid (CDTA) and triethylenetetramine hexacetic acid (TTHA) were more effective than p-aminosalicylic acid (PAS) and isoniazid (INH) in enhancing urinary excretion of Cr, lowering hepatic and blood levels of Cr and restoring inhibited activity of hepatic aldolase. The chromate antidotal property of chelators seem to be related to the combination of nitrogen and oxygen as the electron donating centres.
Research Organization:
Industrial Toxicology Research Centre, Lucknow, India
OSTI ID:
7057746
Journal Information:
Chemosphere; (United States), Journal Name: Chemosphere; (United States) Vol. 14:10; ISSN CMSHA
Country of Publication:
United States
Language:
English