Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium

Journal Article · Sat Oct 01 04:00:00 EDT 1994 · Applied and Environmental Microbiology; (United States)

OSTI ID:6642350

Davis, V M; Stack, M E ^[1]

---

1. Food and Drug Administration, Washington, DC (United States)

Alternariol and alternariol methyl ether were tested in the Ames Salmonella typhimurium assay, and both were shown, with and without metabolic activation, to be nonmutagenic to strains TA98 and TA100. The finding of other investigators that alternariol methyl ether is weakly mutagenic to Ta98 without metabolic activation could have resulted from the presence of a small amount of one of the highly mutagenic altertoxins in the alternariol methyl ether originally tested. 9 refs., 3 figs., 1 tab.

• OSTI ID: 6642350
• Journal Information: Applied and Environmental Microbiology; (United States), Journal Name: Applied and Environmental Microbiology; (United States) Vol. 60:10; ISSN AEMIDF; ISSN 0099-2240
• Country of Publication: United States
• Language: English

Related Subjects

550700* -- Microbiology
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANTIGENS
BACTERIA
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
DISEASES
GENETIC EFFECTS
HAZARDOUS MATERIALS
INFECTIOUS DISEASES
MATERIALS
MICROORGANISMS
PATHOGENS
PLANTS
SALMONELLA
SALMONELLA TYPHIMURIUM
TOXIC MATERIALS
TOXICITY
TOXINS