Quantifying the toxic and mutagenic activity of complex mixtures with Salmonella typhimurium

Journal Article · Sun Mar 01 04:00:00 EST 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530006· OSTI ID:6459583

Somani, S M; Schaeffer, D J; Mack, J O

The toxicity and mutagenicity of 11 compounds individually and in mixtures were quantified in Salmonella typhimurium strains TA98, TA100, and TA1537 by a modification of the Ames spot test. The distance (millimeters) from the center of the petri dish to the bacterial growth front represented the toxic response. When mutagenicity occurred, the distance from the inner radius to the outer radius of the mutagenic growth represented the mutagenic response. Multiple regression analysis was used to quantify the toxicity and mutagenicity of individual compounds in the mixtures. The results indicate that the effects of compounds in mixtures are generally additive.

• Research Organization: Southern Illinois Univ., Springfield
• OSTI ID: 6459583
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 7:3-4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
AMINES
ANTIMETABOLITES
AROMATICS
AZIDES
AZINES
BACTERIA
BENZIDINE
CONDENSED AROMATICS
DINITROPHENOL
DISPERSIONS
DRUGS
FLUORENE
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYDROXY COMPOUNDS
IMIDES
MATHEMATICS
MICROORGANISMS
MIXTURES
MUTAGEN SCREENING
NITRO COMPOUNDS
NITROGEN COMPOUNDS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHENOLS
PYRIDINES
REGRESSION ANALYSIS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
STATISTICS
TOXICITY