Preliminary toxicological study of PYX explosive: (2,6-bis(picrylamino)-3,5-dinitropyridine)

Technical Report · Sat Jan 31 23:00:00 EST 1981

DOI:https://doi.org/10.2172/6642178· OSTI ID:6642178

Drake, G A; London, J E; Smith, D M

The acute oral LD/sub 30//sup 50/ values for PYX explosive for mice and rats is greater than 5 g/kg. According to classical guidelines, the material would be considered slightly or practically nontoxic in both species. Skin application studies in the rabbit with PYX explosive demonstrated that it was cutaneously nonirritating. This material was a very mild and transitory irritant in rabbit eye application studies. The sensitization study in the guinea pig did not show PYX explosive to be deleterious in this regard, although a firm thickening and erythema were seen at the injection sites 72 h after administration.

• Research Organization: Los Alamos Scientific Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6642178
• Report Number(s): LA-8695-MS
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AZINES
BODY
BODY AREAS
CHEMICAL EXPLOSIVES
DATA
EXPERIMENTAL DATA
EXPLOSIVES
EYES
FACE
GUINEA PIGS
HEAD
HETEROCYCLIC COMPOUNDS
INFORMATION
INGESTION
INTAKE
MAMMALS
NITRO COMPOUNDS
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
RABBITS
RATS
RODENTS
SENSE ORGANS
SKIN
TOXICITY
VERTEBRATES