Effect of oxygenated sterol compounds on human bone marrow granulocytic progenitor cells

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Blood; (United States)

OSTI ID:6637551

Hoffman, P C; Richman, C M; Hsu, R C; Chung, J; Scanu, A M; Yachnin, S

Oxygenated sterol compounds are potent inhibitors of sterol and DNA synthesis in mammalian cells. We studied the effects of oxygenated sterols on human marrow granulocytic progenitor cells in vitro (CFU-C)*. 25-Hydroxycholesterol, as well as 6-ketocholestanol, 7-ketocholesterol, and 20 ..cap alpha..-hydroxycholesterol, demonstrated marked inhibition of CFU-C proliferation. The latter effect, which was not a result of direct cytoxicity of the compounds, was reversible by cholesterol, but not by mevalonic acid. We conclude that inhibition of sterol synthesis by oxygenated sterol compounds may be insufficient to explain their suppression of CFU-C proliferation.

• Research Organization: Univ. of Chicago, IL
• OSTI ID: 6637551
• Journal Information: Blood; (United States), Journal Name: Blood; (United States) Vol. 57:1; ISSN BLOOA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BONE MARROW CELLS
CELL PROLIFERATION
CFU
CHOLESTEROL
CONNECTIVE TISSUE CELLS
HYDROXY COMPOUNDS
MAMMALS
MAN
ORGANIC COMPOUNDS
PRIMATES
SIDE EFFECTS
SOMATIC CELLS
STEROIDS
STEROLS
SYNTHESIS
VERTEBRATES