Lipid metabolism in polychlorinated biphenyl-poisoned rats

Journal Article · Sun Jun 01 04:00:00 EDT 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90125-5· OSTI ID:6637349

Yagi, N; Itokawa, Y

To clarify the metabolism of lipids in polychlorinated biphenyl (PCB)-poisoned rats, in vivo and in vitro experiments were carried out. Male Wistar rats were separated into two groups, to one group a commercial flour diet was given and to the other group 500 ppM of PCB (Kanechlor-500) supplemented diet was given for 35 days. These animals were used for the following in vivo and in vitro experiments. (1) In vivo experiment: (/sup 14/C) Acetate or (/sup 14/C) glucose was administered to these rats and respiratory /sup 14/CO/sub 2/ and incorporation of /sup 14/C into the various lipid fractions in liver were determined. It was observed that the conversion into cholesterol from acetate or glucose was significantly accelerated in PCB-poisoned rats. However, no significant change was observed regarding respiratory /sup 14/CO/sub 2/ content between control and PCB-poisoned rats 90 min after administration of (/sup 14/C) acetate or (/sup 14/C) glucose. (2) In vitro experiment: Liver slices from control rats or PCB-poisoned rats were incubatd with (/sup 14/C) acetate or (/sup 14/C) glucose for 90 min at 37/sup 0/C and incorporation of /sup 14/C into various lipid fractions was investigated. In liver slices from PCB-treated rats, conversion into the (/sup 14/C) sterol fraction from (/sup 14/C) acetate and (/sup 14/C) glucose was significantly accelerated.

• Research Organization: Kyoto Univ., Japan
• OSTI ID: 6637349
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 22:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
DIET
DIGESTIVE SYSTEM
GLANDS
LIVER
MAMMALS
METABOLISM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RATS
RODENTS
VERTEBRATES