Phenolic amino-carboxylic acid complexes for forming radiopharmaceuticals

Patent · Tue May 23 04:00:00 EDT 1978

OSTI ID:6635686

Hunt, F C; Wilson, J G

A complex of a chelating agent is formed and labelled with technetium-99m. The chelating agent is either an ethylenediamine carboxylic acid or its salt having a phenolic group at each end of the molecule such as EDDHA and HBED or alternatively the phenolic amino carboxylic acid or its salt having a single phenolate group such as HBG or HBS. The complex is a stannous complex which when labelled with technetium-99m has a good balance of lipo-solubility and water-solubility to permit hepato-biliary imaging. The radiopharmaceutical may be useful for assessing hepato-biliary function in animals including human beings. A particularly useful chelating agent is ethylene-bis-(..cap alpha..-imino-2-hydroxy-5-bromophenyl acetic acid).

• Assignee: Australian Atomic Energy Commission
• Patent Number(s): US 4091088
• OSTI ID: 6635686
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
BIOLOGICAL LOCALIZATION
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMICAL PREPARATION
COMPLEXES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
EDDHA
GLANDS
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIVER
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIN COMPLEXES
YEARS LIVING RADIOISOTOPES