Complex formed from 3-hydroxy-4-formylpyridine, glutamic acid, and technetium: a possible cholescintigraphic agent

Journal Article · Mon Jan 01 04:00:00 EST 1979 · J. Nucl. Med.; (United States)

OSTI ID:6759683

Kono, A; Maeda, T; Karube, Y; Shiokawa, H; Matsushima, Y

In order to obtain a technetium-99m-labeled cholescintigraphic agent suitable for kit preparation, reactions of a variety of aromatic aldehydes, amino acids, and (/sup 99m/Tc) pertechnetate were examined under mild conditions. Aqueous solutions of the three reactants were heated in a boiling-water bath and the products analyzed by means of thin-layer chromatography for the formation of organic technetium complexes. 3-Hydroxy-4-formylpyridine (HFP) and 1-methyl-3-hydroxy-4-formylpyridinium chloride (N-Me-HFP) formed the complex with excellent yields, whereas 3-hydroxy-2-formylpyridine, 4-nitrosalicylaldehyde, salicylaldehyde, and isonicotinaldehyde did not. The complex is concluded to be the Tc-99m chelate of the Schiff base formed from the aldehyde and amino acid. Scintigrams, biliary excretion, and the effect of pancreozymin were examined in rabbits administered with the complex of HFP, glutamic acid, and Tc-99m. The results indicate that it is promising as a cholescintigraphic agent.

• Research Organization: Kyushu Cancer Center Research Inst., Fukuoka, Japan
• OSTI ID: 6759683
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:1; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
AMINES
AMINO ACIDS
AMMONIUM COMPOUNDS
ANIMALS
AQUEOUS SOLUTIONS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CHEMISTRY
CLEARANCE
COMPLEXES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISPERSIONS
DRUGS
EXCRETION
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
MIXTURES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
PYRIDINIUM COMPOUNDS
QUATERNARY COMPOUNDS
RABBITS
RADIOACTIVE MATERIALS
RADIOCHEMISTRY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SOLUTIONS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES