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Inhibition of x-ray- and ultraviolet light-induced transformation in vitro by modifers of poly(ADP-ribose) synthesis

Conference · · Radiat. Res.; (United States)
OSTI ID:6629340
; ; ;

Neoplastic transformation in vitro of hamster embryo cells and mouse C3H 10T1/2 cells by X rays and ultraviolet light was suppressed by benzamide or 3-aminobenzamide, agents which inhibit poly(ADP-ribose) polymerization. Suppression was observed under conditions in which the inhibitors reduce poly(ADP-ribose) polymerization by about 75% and increase sister chromatid exchange frequencies, but have no influence on repair of X-ray and uv damage and reportedly have no detectable side effects on nucleotide precursor metabolism. These findings suggest that the mechanisms regulating neoplastic transformation differ from those regulating mutagenesis and sister chromatid exchanges and are mediated via alterations in poly(ADP-ribosylation), causing changes in gene control and expression.

Research Organization:
Columbia Univ., New York, NY
OSTI ID:
6629340
Report Number(s):
CONF-830220-
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
560111 -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADP
AMIDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DNA
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
EXTREME ULTRAVIOLET RADIATION
FIBROBLASTS
HAMSTERS
IN VITRO
IONIZING RADIATIONS
MAMMALS
MICE
MUTATIONS
NUCLEIC ACIDS
NUCLEOTIDES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
STRAND BREAKS
ULTRAVIOLET RADIATION
VERTEBRATES
X RADIATION