Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
Malignant transformation in vitro of hamster embryo cells and mouse C3H 10T1/2 cells by x-rays, ultraviolet light, and chemical carcinogens was inhibited by benzamide and by 3-aminobenzamide at concentrations that are specific for inhibition of poly(ADP-ribose) formation. These compounds slow the ligation stage of repair of x-ray and alkylation damage but not of ultraviolet light damage. At high concentrations they also inhibited de novo synthesis of DNA purines and DNA methylation by S-adenosylmethionine. The suppression of transformation by the benzamides is in striking contrast to their reported effectiveness in enhancing sister chromatid exchange, mutagenesis, and killing in cells exposed to alkylating agents. Their results suggest that mechanisms regulating malignant transformation are different from those regulating DNA repair, sister chromatid exchange, and mutagenesis and may be associated with changes in gene regulation and expression caused by alterations in poly(ADP-ribosyl)ation.
- Research Organization:
- Columbia Univ., New York, NY
- OSTI ID:
- 5005390
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 81; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Inhibition of x-ray- and ultraviolet light-induced transformation in vitro by modifers of poly(ADP-ribose) synthesis
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Effect of inhibitors of poly(ADP-ribose)polymerase on the radiation response of HeLa S3 cells
Conference
·
Wed Aug 01 00:00:00 EDT 1984
· Radiat. Res.; (United States)
·
OSTI ID:6629340
Differences in the regulation by poly(ADP-ribose) of repair of DNA damage from alkylating agents and ultraviolet light according to cell type
Journal Article
·
Wed Aug 10 00:00:00 EDT 1983
· J. Biol. Chem.; (United States)
·
OSTI ID:6241557
Effect of inhibitors of poly(ADP-ribose)polymerase on the radiation response of HeLa S3 cells
Journal Article
·
Tue Aug 01 00:00:00 EDT 1989
· Radiation Research; (USA)
·
OSTI ID:5543568
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CARBON 14 COMPOUNDS
CELL TRANSFORMATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
ENZYME INHIBITORS
EXTREME ULTRAVIOLET RADIATION
FIBROBLASTS
HAMSTERS
IN VITRO
INHIBITION
IONIZING RADIATIONS
LABELLED COMPOUNDS
MAMMALS
MICE
NITROSO COMPOUNDS
NUCLEOTIDES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
SYNTHESIS
TRITIUM COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CARBON 14 COMPOUNDS
CELL TRANSFORMATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EMBRYONIC CELLS
ENZYME INHIBITORS
EXTREME ULTRAVIOLET RADIATION
FIBROBLASTS
HAMSTERS
IN VITRO
INHIBITION
IONIZING RADIATIONS
LABELLED COMPOUNDS
MAMMALS
MICE
NITROSO COMPOUNDS
NUCLEOTIDES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
SYNTHESIS
TRITIUM COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES
X RADIATION