Nonspecific inhibition of alloantigen-induced proliferation by bone marrow natural regulatory cells
Conference
·
· Transplant. Soc., Int. Cong., Proc.; (United States)
OSTI ID:6620124
We have previously reported that a lymphocyte-enriched fraction ofmurine bone marrow (BML) contains natural regulatory cells (NRC) that can inhibit in vitro proliferative and cytotoxic responses to alloantigens on a dose-dependent basis. In view of the potential importance of these cells to the outcome of bone marrow transplantation, we have undertaken a series of studies designed to inestigate the properties of the effector cell(s). Since clinical and experimental bone marrow transplantation is often performed by inoculating histoincompatible marrow into irradiated hosts, we have investigated the effects of irradiation on NRC and their ability to function across major and minor histocompatibility barriers. In this brief communication, we report that NRC can nonspecifically inhibit cellular immune responses across histocompatibility barriers and are not affected by high doses of irraddiation. In addition, we report that NRC are not T or B lymphocytes.
- Research Organization:
- Univ. of Washington, Seattle
- OSTI ID:
- 6620124
- Conference Information:
- Journal Name: Transplant. Soc., Int. Cong., Proc.; (United States) Journal Volume: 13:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301 -- Cytology-- Tracer Techniques
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EVALUATION
GAMMA RADIATION
GLOBULINS
GRAFT-HOST REACTION
IMMUNITY
IMMUNOGLOBULINS
INHIBITION
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TRANSPLANTS
VERTEBRATES
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EVALUATION
GAMMA RADIATION
GLOBULINS
GRAFT-HOST REACTION
IMMUNITY
IMMUNOGLOBULINS
INHIBITION
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TRANSPLANTS
VERTEBRATES