Osteonecrosis in patients irradiated for head and neck carcinoma

Journal Article · Wed Apr 15 04:00:00 EST 1981 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(19810415)47:8<1980::AID-CNCR2820470813>3.0.CO;2-Y· OSTI ID:6619871

Morrish, Jr, R B; Chan, E; Silverman, S Jr; Meyer, J; Fu, K K; Greenspan, D

One hundred patients irradiated for cancers of the oral cavity, oropharynx, and nasopharynx were evaluated for the occurrence of osteonecrosis and associated predisposing factors. Selection was based on availability of complete dental records, a minimum of six months follow-up, and treatment fields, which included maxilla and/or mandible. Bone doses were calculated by using radiotherapy treatment records, port films, and isodose distributions. Osteonecrosis developed in 19 of 78 dentulous patients and in 3 of 22 edentulous patients. The time of development of osteonecrosis varied; in 15 cases osteonecrosis occurred more than one year after treatment. The most important risk factor for the development of osteonecrosis was the radiation dose to bone, particularly in the less vascular mandible. Osteonecrosis developed in 85% of the dentulous patients and in 50% of the edentulous patients who received more than 7500 rads to the bone. None of the patients who received less than 6500 rads developed osteonecrosis. The risk was significantly greater when teeth were removed after therapy compared with those individuals with extractions before radiation or no extractions at all.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6619871
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 47:8; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
EXTERNAL IRRADIATION
HEAD
INJURIES
IONIZING RADIATIONS
IRRADIATION
JAW
LOCAL RADIATION EFFECTS
MEDICINE
NECK
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
OSTEORADIONECROSIS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
SKULL
TEETH
THERAPY