Osteonecrosis in patients with malignant lymphoma: a review of twenty-five cases

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(19810901)48:5<1245::AID-CNCR2820480532>3.0.CO;2-E· OSTI ID:6035793

Engel, I A; Straus, D J; Lacher, M; Lane, J; Smith, J

A retrospective study of 25 patients with malignant lymphoma who had osteonecrosis of either the femoral or humeral head(s) was undertaken. The common factor present among all patients was the administration of intermittent steroid-containing combination chemotherapy. Seventeen Hodgkin's disease patients received chemotherapy predominantly consisting of an alkylating agent, vincristine, procarbazine, and moderate amounts of prednisone. The non-Hodgkin's lymphoma patients were on various moderate dosage steroid-containing protocols, except three who received prolonged high-dose steroid-containing chemotherapy regimens. Sixteen of the 17 Hodgkin's disease patients and five of the eight non-Hodgkin's lymphoma patients received radiotherapy to the bones that subsequently developed osteonecrosis. Two of the three non-Hodgkin's lymphoma patients who were not irradiated were treated with high-dose steroid-containing chemotherapy regimens. Symptoms developed in patients 12 months to 32 months after completion of chemotherapy and radiotherapy, respectively. Osteonecrosis was a long-term complication of treatment between 1970 and 1979 and occurred in 1.6% of the Hodgkin's disease and 0.12% of the non-Hodgkin's lymphoma patients treated. The authors conclude that the patients at highest risk for this complication are those who receive both radiotherapy to the affected bone(s) and intermittent steroid-containing multiple drug chemotherapy.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY
• OSTI ID: 6035793
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 48:5; ISSN CANCA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKALOIDS
ANTIMITOTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBAZIDES
CARBONIC ACID DERIVATIVES
CHEMOTHERAPY
CORTICOSTEROIDS
DELAYED RADIATION EFFECTS
DISEASES
DRUGS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INDOLES
INJURIES
KETONES
LOCAL RADIATION EFFECTS
LYMPHOMAS
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OSTEORADIONECROSIS
PATHOLOGICAL CHANGES
PATIENTS
PREDNISONE
PREGNANES
PYRROLES
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
STEROID HORMONES
STEROIDS
THERAPY
VINBLASTINE