Osteonecrosis in patients treated with definitive radiotherapy for squamous cell carcinomas of the oral cavity and naso- and oropharynx

Conference · Tue Jun 01 04:00:00 EDT 1976 · Radiology; (United States)

OSTI ID:7352685

Bedwinek, J M; Shukovsky, L J; Fletcher, G H; Daley, T E

A group of 381 patients with squamous cell carcinoma of the oral cavity and naso- and oropharynx treated with definitive radiotherapy were analyzed with respect to the incidence and precipitating factors of mandibular osteonecrosis. Elective dental extraction prior to therapy increased the incidence, and dental conservation decreased it. Spontaneous osteonecrosis did not occur with doses less than 6,000 rads in 6 weeks, and was uncommon (1.8 percent) at doses under 7,000 rads in 7 weeks. At doses over 7,000 rads, osteonecrosis developed in 9 percent. The incidence was greater in patients with tumors near bone (9.4 percent) than in those with tumors not next to bone (2.1 percent). (auth)

• Research Organization: Univ. of Texas System Cancer Center, Houston
• OSTI ID: 7352685
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 119:3
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
INJURIES
JAW
LOCAL RADIATION EFFECTS
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
OSTEORADIONECROSIS
PATHOLOGICAL CHANGES
PATIENTS
PHARYNX
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
SKULL
THERAPY