Prevention of the induction of allospecific cytotoxic T lymphocyte and delayed-type hypersensitivity responses by ultraviolet irradiation of corneal allografts
Journal Article
·
· Transplantation; (USA)
- Univ. of Texas Southwestern Medical Center, Dallas (USA)
The effect of ultraviolet radiation (UVR) on the immunogenicity of corneal allografts was examined in a mouse model. Corneal allografts differing from the host at the entire MHC and multiple minor H loci were subjected to 200 mJ/cm2 of UVB irradiation immediately prior to heterotropic transplantation. Analysis of cytotoxic T lymphocyte and delayed-type hypersensitivity responses revealed that UVR treated corneal grafts failed to induce either CTL or DTH responses in C57BL/6 recipients. UVB treatment abolished the immunogenicity of highly immunogenic corneal grafts containing either resident or infiltrating donor-specific Langerhans cells. Sequential grafting experiments demonstrated that UVB-treated grafts rendered the hosts anergic to subsequent immunization with highly immunogenic corneal limbus grafts that contained dense concentrations of Ia+ Langerhans cells of donor origin. The results indicate that UV treatment not only reduces the immunogenicity of the corneal allograft but may also render it tolerogenic.
- OSTI ID:
- 6616495
- Journal Information:
- Transplantation; (USA), Journal Name: Transplantation; (USA) Vol. 50:2; ISSN 0041-1337; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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560120* -- Radiation Effects on Biochemicals
Cells
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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BLOOD CELLS
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Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
CORNEA
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
IMMUNITY
LEUKOCYTES
LYMPHOCYTES
MATERIALS
ORGANS
RADIATIONS
RADIOINDUCTION
SENSE ORGANS
SOMATIC CELLS
TRANSPLANTS
ULTRAVIOLET RADIATION