Ultraviolet irradiated corneal allografts include antigen scientific unresponsiveness
Conference
·
· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
OSTI ID:5241278
- Univ. of Texas, Dallas (United States)
The effect of ultraviolet (UV) irradiation on the immunogenicity of corneal allografts was examined in a mouse model. BALB/c corneal allografts were exposed to 200 mJ/cm{sup 2} of UVB irradiation immediately prior to heterotopic transplantation of C57BL/6 recipients. Analysis of cytotoxic T lymphocyte (CTL) and delayed-type hypersensitivity (DTH) responses revealed profound impairment of both forms of cell-mediated immunity. Mice grafted with UVB irradiated corneal grafts 7 days prior to immunization with nonirradiated, immunogenic corneal grafts failed to mount either allospecific CTL or DTH responses. Suppression of DTH responses was cyclophosphamide sensitive; C57BL/6 hosts treated with cyclophosphamide one day prior to receiving UVB irradiated corneal grafts developed normal DTH responses. Allospecific suppression could be transferred to naive recipients using spleen cells from host grafted with UV irradiated corneal allografts. The results indicated that UVB irradiation not only rendered corneal allografts nonimmunogenic but also tolerogenic.
- OSTI ID:
- 5241278
- Report Number(s):
- CONF-9104107--
- Conference Information:
- Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Prevention of the induction of allospecific cytotoxic T lymphocyte and delayed-type hypersensitivity responses by ultraviolet irradiation of corneal allografts
Mechanisms of allograft rejection of corneal endothelium
Inability of donor total body irradiation to prolong survival of vascularized bone allografts: Experimental study in the rat
Journal Article
·
Wed Aug 01 00:00:00 EDT 1990
· Transplantation; (USA)
·
OSTI ID:6616495
Mechanisms of allograft rejection of corneal endothelium
Journal Article
·
Thu Jul 01 00:00:00 EDT 1982
· Invest. Ophthalmol. Visual Sci.; (United States)
·
OSTI ID:6725254
Inability of donor total body irradiation to prolong survival of vascularized bone allografts: Experimental study in the rat
Journal Article
·
Sun Jul 01 00:00:00 EDT 1990
· Journal of Reconstructive Microsurgery; (USA)
·
OSTI ID:5838643
Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
CORNEA
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
IMMUNE REACTIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SENSE ORGANS
SOMATIC CELLS
TRANSPLANTS
ULTRAVIOLET RADIATION
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
CORNEA
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
IMMUNE REACTIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SENSE ORGANS
SOMATIC CELLS
TRANSPLANTS
ULTRAVIOLET RADIATION
VERTEBRATES