Assessment of the immunotoxic potential of the fungicide dinocap in mice

Technical Report · Wed Jan 01 04:00:00 EST 1992

OSTI ID:6616276

Smialowicz, R J; Luebke, R W; Riddle, M M

The immunotoxic potential of dinocap was evaluated in female C57BL/6J mice following in vivo and in vitro exposure to the fungicide. In in vivo studies, groups of mice were dosed with technical grade dinocap at dosages ranging from 12.5 to 50 mg/kg/d and selected immune functions examined. Twelve days of dosing with dinocap at 25 mg/kg/d resulted in decreased thymus weights and cellularity, and increased spleen weights. Lymphoproliferative responses to concanavalin A (Con A) and phytohemagglutinin (PHA) were reduced in thymocytes from mice dosed at 25 mg/kg/d dinocap. The cytotoxic T lymphocyte (CTL) response to P815 mastocytoma cells was enhanced in mice exposed for 7 days to 25 mg/kg/d dinocap. In vitro studies using murine thymocytes cultured with dinocap (10 ug/ml for 72 hr) resulted in suppression of the proliferative response to Con A and PHA. These results suggest that dinocap is immunotoxic in the mouse, causing effects on T lymphocytes.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
• OSTI ID: 6616276
• Report Number(s): PB-93-156230/XAB; EPA--600/J-93/018
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOHYDRATES
CONCANAVALIN A
CONNECTIVE TISSUE CELLS
FUNCTIONS
FUNGICIDES
HEMAGGLUTININS
IN VITRO
IN VIVO
LECTINS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MITOGENS
MUCOPROTEINS
ORGANIC COMPOUNDS
ORGANS
PESTICIDES
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PROTEINS
RODENTS
SACCHARIDES
SOMATIC CELLS
SPLEEN
THYMOCYTES
THYMUS
TOXICITY
VERTEBRATES