Effects of macrocyclic trichothecene mycotoxins on the murine immune system
The macrocyclic trichothecenes are a unique group of toxins which have some antileukemic properties. In the first study, verrucarin A and roridin A were examined. Both mycotoxins were administered intraperitoneally at an equitoxic dose of 0.35 mg/kg to CD-1 mice. Lymphocyte proliferation was studied after animals were dosed with verrucarin A. After day 2, no differences in {sup 3}H-thymidine incorporation were observed using concanavalin A (Con A), phytohemagglutinin (PHA), pokeweed mitogen (PWM), or lipopolysaccharide (LPS). On day 4, DNA synthesis induced by Con A, PHA, and PWM increased significantly. On day 7, PHA stimulation increased above controls while Con A, PWM, and LPS responses were not significantly different. In contrast, roridin A decreased PHA stimulation only on day 7. In the second study the mycotoxins roritoxin B, myrotoxin B, roridin A, verrucarin A, 16-hydroxyverrucarin A, verrucarin J, baccharinoid B12, roridin D, roridin E, baccharinoid B4, and baccharinoid B5 were investigated. In the third study lymphocytes were cultured with each of the mycotoxins for 48 hr to assess their lethality.
- Research Organization:
- Utah State Univ., Logan, UT (USA)
- OSTI ID:
- 5265281
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
AGGLUTININS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIBODIES
ANTIGENS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOHYDRATES
CELL PROLIFERATION
CONCANAVALIN
CONNECTIVE TISSUE CELLS
HEMAGGLUTININS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LEUKOCYTES
LIPIDS
LIPOPOLYSACCHARIDES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MITOGENS
MUCOPROTEINS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PROTEINS
PYRIMIDINES
RETICULOENDOTHELIAL SYSTEM
RIBOSIDES
RODENTS
SACCHARIDES
SENSITIVITY
SOMATIC CELLS
THYMIDINE
TISSUES
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES