Effect of low dose rate on recovery of hemopoietic and stromal progenitor cells in gamma-irradiated mouse bone marrow
Journal Article
·
· Radiat. Res.; (United States)
Long-term recovery of mouse hemopoietic stem cells (CFU-S and CFU-S per colony), granulocyte-macrophage precursor cells (GM-CFC), and stromal colony-forming units (CFU-F) after doses up to 12.5 Gy was almost complete by 1 year when the dose rate was reduced to 0.0005 Gy/min compared to incomplete recovery after doses up to only 6.5 Gy given at greater than 0.7 Gy/min. This sparing effect of dose rate on long-term hemopoietic recovery is in contrast to the generally reported lack of dependence on dose rate for acute survival of hemopoietic progenitors after doses up to 5 Gy. The present results are compatible with the hypothesis that good recovery of the stroma should be reflected in the long-term recovery of hemopoiesis.
- Research Organization:
- Christie Hospital, Manchester (England)
- OSTI ID:
- 6599612
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 115:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BONE MARROW
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
MACROPHAGES
MAMMALS
MICE
ORGANS
PHAGOCYTES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BONE MARROW
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
MACROPHAGES
MAMMALS
MICE
ORGANS
PHAGOCYTES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES