Response of stromal progenitor cells in mouse marrow to graded repeated doses of x rays or neutrons
Journal Article
·
· Radiat. Res.; (United States)
After four repeated doses of 1.5 Gy X rays to mice (3-week intervals), the number of colonies containing fibroblasts that could be grown in vitro from femoral marrow recovered to control numbers by 80 days. After four higher doses, recovery was incomplete, and after four doses of 4.5 Gy, the number was half of the control level up to 1 year after irradiation. After four doses of 14.7 MeV neutrons, no threshold was detected for this late effect, and the RBE was about 2 at 4.5 Gy X rays and about 6 at 1.5 Gy X rays. The RBE for the acute effect on the stromal progenitor cells was also about 2 at 4.5 Gy X rays. The stromal progenitor cells could not be spared relative to hemopoietic stem cells (CFU-S) after neutrons, in contrast to the sparing observed after low-dose fractions of X rays. Experimetns with local X irradiations of the leg, and with subcutaneous transplants of femora, revealed no significant recovery of stromal progenitor cells due to migration. However, recovery in situ could be enhanced slightly by marrow grafts.
- Research Organization:
- Paterson Labs., Christie Hospital and Holt Radium Inst., Manchester, England
- OSTI ID:
- 5427945
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 96:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CELL KILLING
CFU
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
HADRONS
HEMATOPOIETIC SYSTEM
IN VITRO
IONIZING RADIATIONS
MAMMALS
MICE
NEUTRONS
NUCLEONS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
RODENTS
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES
X RADIATION
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CELL KILLING
CFU
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
HADRONS
HEMATOPOIETIC SYSTEM
IN VITRO
IONIZING RADIATIONS
MAMMALS
MICE
NEUTRONS
NUCLEONS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
RODENTS
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES
X RADIATION