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Chelatable lead body burden (by calcium-disodium EDTA) and blood lead concentration in man

Journal Article · · J. Occup. Med.; (United States)
; ;
The chelatable part of lead body burden was measured in 32 workers and seven office workers after an infusion test with CaNa/sub 2/EDTA. The workers had been exposed to lead at a lead and zinc processing unit for one to three years (mean one year). There was good correlation (r = 0.87) between blood lead and chelatable urinary lead excretion described by the equation y = 0 07.10/sup 0.46 x/. From this equation it can be predicted that the generally accepted limit value for chelatable urinary lead excretion, 0.42 ..mu..mol/mmol CaNa/sub 2/EDTA administered per 24 hours (3.1 ..mu..mol/24 hours or 650 ..mu..g/24 hours), corresponds to a blood lead concentration (PbB) of 1.7 ..mu..mol/l (or 35 ..mu..g/100 ml), which is lower than the commonly accepted limit value of 2.9 ..mu..mol/1 (or 60..mu..g/100 ml) for occupationally lead-exposed persons. There was a better correlation between the chelatable lead excretion and the urinary ALA-excretion (r = 0.45; p < 0.001) than between PbB and the urinary ALA-excretion (r = 0.26; p > 0.05).
Research Organization:
Univ. of Copenhagen, Denmark
OSTI ID:
6597034
Journal Information:
J. Occup. Med.; (United States), Journal Name: J. Occup. Med.; (United States) Vol. 23:1; ISSN JOCMA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism &amp; Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY BURDEN
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATES
CHELATING AGENTS
CHRONIC EXPOSURE
CLEARANCE
COMPLEXES
CORRELATIONS
DATA
EDTA
ELEMENTS
EXCRETION
EXPERIMENTAL DATA
INFORMATION
LEAD
MAMMALS
MAN
MATERIALS
MEASURING METHODS
METALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
URINE
VERTEBRATES
WASTES