Influence of sex and of chelation therapy on erythrocyte protoporphyrin and urinary delta-aminolevulinic acid in lead-exposed workers

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · J. Occup. Med.; (United States)

OSTI ID:5522440

Roels, H A; Balis-Jacques, M N; Buchet, J P; Lauwerys, R R

A study was undertaken to compare the susceptibility to lead of the heme biosynthetic pathway (blood lead concentration up to 60 ..mu..g/100 ml) of male and of female lead workers. At exposures of similar duration and intensity, adult non-pregnant women were more susceptible than men to some biological effects of lead as reflected by an earlier and larger increase of free erythrocyte protoporphyrin (FEP) and urinary delta-aminolevulinic acid (ALAU) levels at comparable blood lead concentrations (PbB). Preliminary results provided suggestive evidence that plasma lead concentration might be higher in lead-exposed women than in lead-exposed men. The second part of the paper reports a study of male lead workers, the majority of whom had had several courses of CaNa/sub 2/-EDTA therapy in recent years. Comparison of the workers who had undergone chelation therapy and of untreated workers from the same plant demonstrated clearly that chelation therapy markedly altered the interrelationships of PbB, PbU, FEP, and ALAU.

• Research Organization: Univ. of Louvain, Brussels, Belgium
• OSTI ID: 5522440
• Journal Information: J. Occup. Med.; (United States), Journal Name: J. Occup. Med.; (United States) Vol. 21:8; ISSN JOCMA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHELATES
COMPLEXES
DATA
DATA FORMS
EXPERIMENTAL DATA
FEMALES
HEMATOPOIETIC SYSTEM
INFORMATION
ISOLATED VALUES
LEAD COMPOUNDS
MALES
MAMMALS
MAN
MEN
MEN DOSE-RESPONSE RELATIONSHIPS
NUMERICAL DATA
PRIMATES
SEX DEPENDENCE
THERAPY
VERTEBRATES
WOMEN