Inactivation of SV40 replication by derivatives of benzo(a)pyrene

Journal Article · Mon May 28 04:00:00 EDT 1979 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(79)92103-X· OSTI ID:6594350

Chang, G T; Harvey, R G; Hsu, W T; Weiss, S B

When African green monkey kidney cell lines, infected with simian virus 40, were exposed to benzo(a)pyrene-7,8-dihydrodiol or anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide, inhibition of progeny virus formation was observed. Studies on (/sup 3/H)thymidine incorporation indicate that SV40 DNA synthesis is markedly impaired for the first 12 hours following BPDE treatment; 24 to 36 hours later, however, SV40 DNA synthesis is almost normal. These data suggest that the inhibition of SV40 DNA synthesis by BP derivatives is reversible and that the observed reduction in viral titer requires some other explanation.

• Research Organization: Univ. of Chicago, IL
• OSTI ID: 6594350
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 88:2; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATION
ANIMAL CELLS
ANIMALS
AROMATICS
AZINES
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CELL PROLIFERATION
CHEMICAL REACTIONS
CONDENSED AROMATICS
DNA
DNA REPLICATION
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INACTIVATION
INFECTIVITY
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
MICROORGANISMS
MONKEYS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARASITES
PRIMATES
PYRIMIDINES
RIBOSIDES
THYMIDINE
TRITIUM COMPOUNDS
VERTEBRATES
VIRUSES