Cancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality

Journal Article · Tue Feb 01 04:00:00 EST 1994 · Radiation Research; (United States)

DOI:https://doi.org/10.2307/3578894· OSTI ID:6593240

Ron, E ^[1]; Preston, D L; Mabuchi, Kiyohiko ^[2]; Thompson, D E ^[3]; Soda, Midori ^[4]

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1. Radiation Effects Research Foundation, Hiroshima (Japan) National Cancer Institute, Bethesda, MD (United States)
2. Radiation Effects Research Foundation, Hiroshima (Japan)
3. Radiation Effects Research Foundation, Hiroshima (Japan) George Washington Univ., Rockville, MD (United States) Radiation Effects Research Foundation, Nagasaki (Japan)
4. Radiation Effects Research Foundation, Nagasaki (Japan)

This report compares cancer incidence and mortality among atomic bomb survivors in the Radiation Effects Research Foundation Life Span Study (LSS) cohort. Because the incidence data are derived from the Hiroshima and Nagasaki tumor registries, case ascertainment is limited to the time (1958-1987) and geographic restrictions (Hiroshima and Nagasaki) of the registries, whereas mortality data are available from 1950-1987 anywhere in Japan. With these conditions, there were 9,014 first primary incident cancer cases identified among LSS cohort members compared with 7,308 deaths for which cancer was listed as the underlying cause of death on death certificates. When deaths were limited to those occurring between 1958-1987 in Hiroshima or Nagasaki, there were 3,155 more incident cancer cases overall, and 1,262 more cancers of the digestive system. For cancers of the oral cavity and pharynx, skin, breast, female and male genital organs, urinary system and thyroid, the incidence series was at least twice as large as the comparable mortality series. Although the incidence and mortality data are dissimilar in many ways, the overall conclusions regarding which solid cancers provide evidence of a significant dose response generally confirm the mortality findings. When either incidence or mortality data are evaluated, significant excess risks are observed for all solid cancers, stomach, colon, liver (when it is defined as primary liver cancer or liver cancer not otherwise specified on the death certificate), lung, breast, ovary and urinary bladder. No significant radiation effect is seen for cancers of the pharynx, rectum, gallbladder, pancreas, nose, larynx, uterus, prostate or kidney in either series. There is evidence of a significant excess of nonmelanoma skin cancer in the incidence data, but not in the mortality series. 19 refs., 2 figs., 10 tabs.

• OSTI ID: 6593240
• Journal Information: Radiation Research; (United States), Journal Name: Radiation Research; (United States) Vol. 137:2, Suppl; ISSN 0033-7587; ISSN RAREAE
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COMPARATIVE EVALUATIONS
DEVELOPED COUNTRIES
DISEASE INCIDENCE
DISEASES
EVALUATION
HIROSHIMA
HUMAN POPULATIONS
JAPAN
MEDICAL RECORDS
MORTALITY
NAGASAKI
NEOPLASMS
POPULATIONS
RADIATION EFFECTS
RISK ASSESSMENT