Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987

Journal Article · Tue Feb 01 04:00:00 EST 1994 · Radiation Research; (United States)

DOI:https://doi.org/10.2307/3578892· OSTI ID:6440150

Thompson, D E ^[1]; Soda, Midori ^[2]; Izumi, Shizue; Mabuchi, Kiyohiko ^[3]; Ron, E; Tokunaga, Masayoshi ^[4]; Ochikubo, Sachio ^[5]; Sugimoto, Sumio ^[6]; Ikeda, Takayoshi ^[7]; Terasaki, Masayuki ^[8]

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1. Radiation Effects Research Foundation, Nagasaki (Japan) George Washington Univ., Rockville, MD (United States) Radiation Effects Research Foundation, Hiroshima (Japan)
2. Radiation Effects Research Foundation, Nagasaki (Japan)
3. Radiation Effects Research Foundation, Hiroshima (Japan)
4. Radiation Effects Research Foundation, Hiroshima (Japan) National Cancer Institute, Bethesda, MD (United States)
5. Hiroshima City Medical Association (Japan)
6. Hiroshima Prefectural Medical Association (Japan)
7. Nagasaki Univ. Medical School (Japan)
8. Nagasaki City Medical Association (Japan); and others

This report presents, for the first time, comprehensive data on the incidence of solid cancer and risk estimates for A-bomb survivors in the extended Life Span Study (LSS-E85) cohort. Among 79,972 individuals, 8613 first primary solid cancers were diagnosed between 1958 and 1987. As part of the standard registration process of the Hiroshima and Nagasaki tumor registries, cancer cases occurring among members of the LSS-E85 cohort were identified using a computer linkage system supplemented by manual searches. Special efforts were made to ensure complete case ascertainment, data quality and data consistency in the two cities. For all sites combined, 75% of the cancers were verified histologically, 6% were diagnosed by direct observation, 8% were based on a clinical diagnosis, and 12.6% were ascertained by death certificate only. A standard set of analyses was carried out for each of the organs and organ systems considered. Depending on the cancer site, Dosimetry System 1986 (DS86) organ or kerma doses were used for computing risk estimates. Analyses were based on a general excess relative risk model (the background rate times one plus the excess relative risk). Analyses carried out for each site involved fitting the background model with no dose effect, a linear dose-response model with no effect modifiers, a linear-quadratic dose-response model with no effect modifiers, and a series of linear dose-response models that included each of the covariates (sex, age at exposure, time since exposure, attained age and city) individually as effect modifiers. Because the tumor registries ascertain cancers in the registry catchment areas only, an adjustment was made for the effects of migration. In agreement with prior LSS findings, a statistically significant excess risk for all solid cancers was demonstrated. 116 refs., 8 figs., 78 tabs.

• OSTI ID: 6440150
• Journal Information: Radiation Research; (United States), Journal Name: Radiation Research; (United States) Vol. 137:2, Suppl; ISSN 0033-7587; ISSN RAREAE
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DEVELOPED COUNTRIES
DISEASE INCIDENCE
DISEASES
HIROSHIMA
HUMAN POPULATIONS
JAPAN
MEDICAL RECORDS
MORTALITY
NAGASAKI
NEOPLASMS
POPULATIONS
RADIATION EFFECTS
RISK ASSESSMENT