Cancer incidence in atomic bomb survivors. Part I: Use of the tumor registries in Hiroshima and Nagasaki for incidence studies

Journal Article · Tue Feb 01 04:00:00 EST 1994 · Radiation Research; (United States)

DOI:https://doi.org/10.2307/3578891· OSTI ID:6593163

Mabuchi, Kiyohiko; Tokunaga, Masayoshi; Preston, D L ^[1]; Soda, Midori ^[2]; Ron, E ^[3]; Ochikubo, Sumio ^[4]; Ikeda, Takayoshi ^[5]; Terasaki, Masayuki ^[6]; Thompson, D E ^[7]

---

1. Radiation Effects Research Foundation, Hiroshima (Japan)
2. Radiation Effects Research Foundation, Nagasaki (Japan)
3. Radiation Effects Research Foundation, Hiroshima (Japan) National Cancer Institute, Bethesda, MD (United States)
4. Hiroshima Perfectural Medical Association (Japan)
5. Nagasaki Univ. School of Medicine (Japan)
6. Nagasaki City Medical Association (Japan)
7. Radiation Effects Research Foundation, Nagasaki (Japan) Radiation Effects Research Foundation, Hiroshima (Japan) George Washington Univ., Rockville, MD (United States)

More than 30 years ago, population-based tumor registries were established in Hiroshima and Nagasaki. This report, the first of a series of papers on cancer incidence, describes methodological aspects of the tumor registries and discusses issues of data quality in the context of the Life Span Study (LSS) cohort, the major atomic bomb survivor population. The tumor registries in Hiroshima and Nagasaki are characterized by active case ascertainment based on abstraction of medical records at area hospitals, augmented by tissue registries operational in the area and a number of clinical and pathological programs undertaken over the years among the atomic bomb survivors. Using conventional measures of quality, the Hiroshima and Nagasaki tumor registries have a death certificate-only (DCO) rate of less than 9%, a mortality/incidence (M/I) ratio of about 50%, and a histological verification (HV) rate in excess of 70%, which place these registries among the best in Japan and comparable to many established registries worldwide. All tumor registry data pertaining to the LSS population were assembled, reviewed and handled with special attention given to the quality and uniformity of data based on standardized procedures. Special studies and monitoring programs were also introduced to evaluate the quality of the tumor incidence data in the LSS. Analyses were performed to examine the quality of incidence data overall and across various substrata used for risk assessment such as age, time and radiation dose groups. No significant associations were found between radiation dose and data quality as measured by various indices. These findings warrant the use of the present tumor registry-based data for studies of cancer incidence in the atomic bomb survivors. 41 refs., 2 figs., 10 tabs.

• OSTI ID: 6593163
• Journal Information: Radiation Research; (United States), Journal Name: Radiation Research; (United States) Vol. 137:2, Suppl; ISSN 0033-7587; ISSN RAREAE
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
990301 -- Information Handling-- Data Handling-- (1992-)
A-BOMB SURVIVORS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CONTROL
DEVELOPED COUNTRIES
DISEASE INCIDENCE
DISEASES
HIROSHIMA
HUMAN POPULATIONS
JAPAN
MANAGEMENT
MEDICAL RECORDS
MEDICAL SURVEILLANCE
MORTALITY
NAGASAKI
NEOPLASMS
POPULATIONS
QUALITY CONTROL
RADIATION EFFECTS
RECORDS MANAGEMENT
RISK ASSESSMENT
SURVEILLANCE