New improved synthesis of 2-deoxy-2-(/sup 18/F)fluoro-d-glucose from /sup 18/F-labeled acetyl hypofluorite

Journal Article · Fri Oct 01 00:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6592002

Shiue, C Y ^[1]; Salvadori, P A; Wolf, A P; Fowler, J S; MacGregor, R R

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1. Brookhaven National Lab., Upton, NY

A new improved synthesis of 2-deoxy-2-(/sup 18/F)fluoro-D-glucose (2-/sup 18/FDG, 4) from /sup 18/F-labeled acetyl hypofluorite (1) is described. Reaction of 3,4,6-tri-O-acetyl-D-glucal (2) with 1, generated in situ from (/sup 18/F)F/sub 2/ and ammonium acetate in acetic acid solution at room temperature, gave 2-deoxy-2-(/sup 18/F)fluoro-1,3,4,6-tetra-O-acetyl-..cap alpha..-D-glucopyranose (3). Hydrolysis of compound 3 with 2N HCl gave 2-deoxy-2-(/sup 18/F)fluoro-D-glucose (4) in radiochemical yields of approx.20% in a synthesis time of 70 min from EOB.

• OSTI ID: 6592002
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CHEMICAL PREPARATION
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIOISOTOPES
SACCHARIDES
SYNTHESIS