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Process for the production of 18F-2-deoxy-2-fluoro-D-glucose

Patent ·
OSTI ID:1176553
; ; ; ;
Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding 18F-compound by the reaction of acetyl hypofluorite or the corresponding 18F-compound with 3,4,6-tri-O-acetyl-D-glucal followed by hydrolysis. Process includes the production of the hypofluorite compound at ambient temperature.
Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-76CH00016
Assignee:
The United States of America as represented by the United States Department of Energy (Washington, DC)
Patent Number(s):
H000074
Application Number:
06/469597
OSTI ID:
1176553
Country of Publication:
United States
Language:
English

References (4)

Fluorination with molecular fluorine. A convenient synthesis of 2-deoxy-2-fluoro-D-glucose journal June 1977
A rapid, stereospecific synthesis of 2-deoxy-2-fluoro-D-glucose using the fluoride ion journal January 1982
Author index for volume 22 journal November 1981
Acetyl hypofluorite, the first member of a new family of organic compounds journal January 1981

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
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