Preliminary toxicology study of 3,6-diamino-1,2,4,5-tetrazine
Technical Report
·
OSTI ID:6587557
The calculated acute oral LD 30/50 (lethal dose for 50% of the animals occurring within 30 days after compound administration) value for 3,6-diamino-1,2,4,5-tetrazine (DATZ) was 863 mg/kg in rats. According to classical guidelines, DATZ would be considered slightly to moderately toxic for rats. The calculated acute oral LD [sub 30/50] value was 2,288 mg/kg in mice and would be considered slightly to moderately toxic for mice. Skin application studies using rabbits demonstrated DATZ to be a nonirritant. The eye study using rabbits disclosed DATZ to be a very mild irritant. The sensitization study using guinea pigs did not show DATZ to have potential sensitizing properties.
- Research Organization:
- Los Alamos National Lab., NM (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6587557
- Report Number(s):
- LA-12346-MS; ON: DE93009117
- Country of Publication:
- United States
- Language:
- English
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ORGANIC COMPOUNDS
TOXICITY
BIOASSAY
EYES
GUINEA PIGS
LETHAL DOSES
MICE
RABBITS
RATS
SKIN
ANIMALS
BODY
BODY AREAS
DOSES
FACE
HEAD
MAMMALS
ORGANS
RODENTS
SENSE ORGANS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
ORGANIC COMPOUNDS
TOXICITY
BIOASSAY
EYES
GUINEA PIGS
LETHAL DOSES
MICE
RABBITS
RATS
SKIN
ANIMALS
BODY
BODY AREAS
DOSES
FACE
HEAD
MAMMALS
ORGANS
RODENTS
SENSE ORGANS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology