Preliminary toxicology study of 3,6-diamino-1,2,4,5-tetrazine

Technical Report · Sun Feb 28 23:00:00 EST 1993

OSTI ID:6587557

London, J E

The calculated acute oral LD 30/50 (lethal dose for 50% of the animals occurring within 30 days after compound administration) value for 3,6-diamino-1,2,4,5-tetrazine (DATZ) was 863 mg/kg in rats. According to classical guidelines, DATZ would be considered slightly to moderately toxic for rats. The calculated acute oral LD [sub 30/50] value was 2,288 mg/kg in mice and would be considered slightly to moderately toxic for mice. Skin application studies using rabbits demonstrated DATZ to be a nonirritant. The eye study using rabbits disclosed DATZ to be a very mild irritant. The sensitization study using guinea pigs did not show DATZ to have potential sensitizing properties.

• Research Organization: Los Alamos National Lab., NM (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6587557
• Report Number(s): LA-12346-MS; ON: DE93009117
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BODY
BODY AREAS
DOSES
EYES
FACE
GUINEA PIGS
HEAD
LETHAL DOSES
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
RABBITS
RATS
RODENTS
SENSE ORGANS
SKIN
TOXICITY
VERTEBRATES