Radiosensitization of malignant melanoma. I. The effect of 7-hydroxy-chlorpromazine on the in vivo radiation response of Fortner's melanoma. [X rays; hamsters]
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
A number of investigators have reported the radiosensitizing effects of chlorpromazine (CPZ) in the treatment of malignant melanoma. In the present study, we explored radiosensitization of Fortner's melanoma in the hamster, by use of the 7-hydroxy metabolite (7-OHCPZ) of CPZ. In conjunction with orthovoltage photon radiation (XRT), 7-OHCPZ was found to repress mean tumor growth by as much as 54, 56, 38, and 53%, respectively, compared to XRT alone, 7-OHCPZ alone, CPZ + XRT, and no treatment. These results may be related to the greater affinity for melanin of 7-OHCPZ than CPZ. Possible therapeutic mechanisms are discussed.
- Research Organization:
- Hahnemann Medical Coll. and Hospital, Philadelphia
- OSTI ID:
- 6585583
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 4:9/10; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHLORPROMAZINE
COMPARATIVE EVALUATIONS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
LEGS
LIMBS
LOCAL IRRADIATION
MAMMALS
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTHIAZINES
PSYCHOTROPIC DRUGS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
RODENTS
THERAPY
TRANQUILIZERS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHLORPROMAZINE
COMPARATIVE EVALUATIONS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
LEGS
LIMBS
LOCAL IRRADIATION
MAMMALS
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTHIAZINES
PSYCHOTROPIC DRUGS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
RODENTS
THERAPY
TRANQUILIZERS
VERTEBRATES
X RADIATION