Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma

Journal Article · Sun Jan 31 23:00:00 EST 1982 · Cancer Res.; (United States)

OSTI ID:5205852

Fairchild, R G ^[1]; Greenberg, D; Watts, K P; Packer, S; Atkins, H L; Som, P; Hannon, S J; Brill, A B; Fand, I; McNally, W P

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1. Brookhaven National Lab., Upton, NY

Chlorpromazine (CPZ) distribution was measured in tissues of Syrian golden hamsters bearing Greene melanoma and in BALB/c mice bearing Harding-Passey melanoma. Distribution was evaluated as a function of time (0.5 to 14 days) and as a function of single and multiple doses (up to five) of from 5 to 50 mg CPZ per kg body weight. Routes of administration (i.p., i.v., p.o.) were compared. The physiological behavior of CPZ is of interest as it is used extensively as a tranquilizing drug (Thorazine). Further, since CPZ binds to the pigment melanin, the possibility exists of using CPZ to transport diagnostic or therapeutic agents to melanoma. It was found that, at 2 days postinjection, tumor/tissue concentration ratios exceeded 10 for metabolizing organs, such as liver, and 100 for background tissues, such as blood and muscle. Absolute concentrations of CPZ in tumor exceeding 100 ..mu..g CPZ per g tumor were obtained with both single and multiple doses. This selective high concentration in tumor would make CPZ an ideal vehicle for the transport of boron to tumor for use in neutron capture therapy via the /sup 10/B(n,..cap alpha..)/sup 7/Li reaction.

• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5205852
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 42; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL LOCALIZATION
CENTRAL NERVOUS SYSTEM AGENTS
COMPARATIVE EVALUATIONS
DISEASES
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HAMSTERS
HYDROXY COMPOUNDS
MAMMALS
MEDICINE
MELANIN
MELANOMAS
MICE
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
PIGMENTS
PSYCHOTROPIC DRUGS
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
TISSUE DISTRIBUTION
TRANQUILIZERS
USES
VERTEBRATES