Delineation of a transplanted malignant melanoma with Indium-111-labeled porphyrin. [Hamsters]
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5410795
An indium complex of a cationic, water-soluble, synthetic porphyrin, tetra-4-N-methylpyridyl porphyrin tosylate, has been prepared and evaluated for its selective localization in tumors in Syrian Golden hamsters with flank transplanted malignant melanoma (Fortner MMI). Tumor-to-blood ratios of the compound increase from 42:1 at 6 hr postinjection, at which time activity levels in the tumor exceed those in all other tissues, to 162.1 at 72 hr. Images in one hamster at three time periods clearly delineated the tumor from nontarget background and also demarcated the viable and necrotic zones within the tumor itself.
- Research Organization:
- Lehigh Univ., Bethlehem, PA
- OSTI ID:
- 5410795
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:7; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma
Radiolabeled porphyrin versus gallium-67 citrate for the detection of human melanoma in athymic mice
Radiosensitization of malignant melanoma. I. The effect of 7-hydroxy-chlorpromazine on the in vivo radiation response of Fortner's melanoma. [X rays; hamsters]
Journal Article
·
Sun Jan 31 23:00:00 EST 1982
· Cancer Res.; (United States)
·
OSTI ID:5205852
Radiolabeled porphyrin versus gallium-67 citrate for the detection of human melanoma in athymic mice
Conference
·
Wed Dec 31 23:00:00 EST 1986
·
OSTI ID:6864198
Radiosensitization of malignant melanoma. I. The effect of 7-hydroxy-chlorpromazine on the in vivo radiation response of Fortner's melanoma. [X rays; hamsters]
Journal Article
·
Sat Dec 31 23:00:00 EST 1977
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6585583
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HAMSTERS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MELANOMAS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PORPHYRINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
SYNTHESIS
TISSUE DISTRIBUTION
VERTEBRATES
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HAMSTERS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MELANOMAS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PORPHYRINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
SYNTHESIS
TISSUE DISTRIBUTION
VERTEBRATES