Comparison of methods for assessing photoprotection against ultraviolet A in vivo

Journal Article · Sat Jan 31 23:00:00 EST 1987 · J. Am. Acad. Dermatol.; (United States)

DOI:https://doi.org/10.1016/S0190-9622(87)70048-6· OSTI ID:6585513

Kaidbey, K; Gange, R W

Photoprotection against ultraviolet A (UVA) by three sunscreens was evaluated in humans, with erythema and pigmentation used as end points in normal skin and in skin sensitized with 8-methoxypsoralen and anthracene. The test sunscreens were Parsol 1789 (2%), Eusolex 8020 (2%), and oxybenzone (3%). UVA was obtained from two filtered xenon-arc sources. UVA protection factors were found to be significantly higher in sensitized skin compared with normal skin. Both Parsol and Eusolex provided better and comparable photoprotection (approximately 3.0) than oxybenzone (approximately 2.0) in sensitized skin, regardless of whether 8-methoxypsoralen or anthracene was used. In normal unsensitized skin, Parsol 1789 and Eusolex 8020 were also comparable and provided slightly better photoprotection (approximately 1.8) than oxybenzone (approximately 1.4) when pigmentation was used as an end point. The three sunscreens, however, were similar in providing photoprotection against UVA-induced erythema. Protection factors obtained in artificially sensitized skin are probably not relevant to normal skin. It is concluded that pigmentation, either immediate or delayed, is a reproducible and useful end point for the routine assessment of photoprotection of normal skin against UVA.

• Research Organization: Univ. of Pennsylvania Medical School, Philadelphia
• OSTI ID: 6585513
• Journal Information: J. Am. Acad. Dermatol.; (United States), Journal Name: J. Am. Acad. Dermatol.; (United States); ISSN JAADD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTHRACENE
ANTICOAGULANTS
AROMATICS
BODY
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
COUMARINS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ERYTHEMA
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
IN VIVO
MAMMALS
MAN
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PIGMENTS
PRIMATES
PSORALEN
RADIATION PROTECTION
RADIATIONS
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
SKIN
SKIN DISEASES
SYMPTOMS
ULTRAVIOLET RADIATION
VERTEBRATES