Aphidicolin promotes repair of potentially lethal damage in irradiated mammalian cells synchronized in S-phase
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Aphidicolin, an inhibitor of the ..cap alpha..-polymerase in mammalian cells, at a concentration of 0.5 ..mu..g/ml, is shown to enable cells which are growing exponentially and synchronized in the S-phase of the cell cycle, to repair potentially lethal damage caused by exposure to either x-rays or UV-light. The drug holds cells up in the S-phase which may serve to allow time for repair and could prevent fixation of damage which may occur when the cells progress through the cell cycle. The possible involvement of ..cap alpha..- and ..beta..-polymerase in repair of potentially lethal damage is discussed.
- Research Organization:
- Gesellschaft fur Strahlen-und Umweltforschung, Frankfurt, West Germany
- OSTI ID:
- 6579874
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 104:4; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CYCLE
ELECTROMAGNETIC RADIATION
ENZYME INHIBITORS
ENZYMES
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
NUCLEOTIDYLTRANSFERASES
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
RADIATIONS
RECOVERY
REPAIR
TRANSFERASES
ULTRAVIOLET RADIATION
X RADIATION
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CYCLE
ELECTROMAGNETIC RADIATION
ENZYME INHIBITORS
ENZYMES
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
NUCLEOTIDYLTRANSFERASES
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
RADIATIONS
RECOVERY
REPAIR
TRANSFERASES
ULTRAVIOLET RADIATION
X RADIATION