Structure-activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · J. Pharmacol. Exp. Ther.; (United States)

OSTI ID:6578638

Szabo, S; Reynolds, E S; Unger, S H

Structure-activity relationships were qualitatively and quantitatively examined for 56 chemicals (e.g., derivatives of propionitrile, acrylonitrile and cysteamine) which caused duodenal ulcer and/or adrenocortical necrosis in rats. For the first time the duodenal ulcerogenic property of numerous chemicals has been studied in a rational and predictive manner. Ulcerogenic activity was most intense in the carbonitriles attached to two or three carbon backbones and diminished by shortening, lengthening, branching, unsaturating, halogenating or hydroxylating the carbon chains. Different modes of action are implied. Adrenocorticolytic potency was associated with unsaturation of the carbon chain and substitution of the nitrile by thiol or amine radicals. An action of these chemicals on the central nervous system has been suggested.

• Research Organization: Department of Pathology, Peter Bent Brigham Hospital, Boston, Massachusetts
• OSTI ID: 6578638
• Journal Information: J. Pharmacol. Exp. Ther.; (United States), Journal Name: J. Pharmacol. Exp. Ther.; (United States) Vol. 223:1; ISSN JPETA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLONITRILE
ADRENAL GLANDS
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DRUGS
ENDOCRINE GLANDS
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
MAMMALS
MEA
NECROSIS
NITRILES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROPIOLONITRILE
RADICALS
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SMALL INTESTINE
THIOLS
ULCERS
VERTEBRATES