Barrier and uptake mechanisms in the cerebrovascular response to noradrenaline. [/sup 133/Xe tracer technique, baboons]
Journal Article
·
· Am. J. Physiol.; (United States)
OSTI ID:6572834
Cerebral blood flow (CBF) was measured in 20 baboons by the intra-arterial xenon-133 injection method. The CBF responses to intra-arterial infusions of noradrenaline (NA) were determined. These responses were normally found to be vasodilator and mediated by beta adrenoreceptors. After infusion of substances blocking extraneuronal uptake of NA or opening of the blood-brain barrier, this vasodilation was either abolished or converted to an alpha-receptor mediated vasoconstriction. This suggests that normally the cerebral circulation is protected against noradrenergic vasoconstriction by mechanisms reducing the concentration of NA in the tunica media to below threshold for alpha-adrenoreceptor stimulation.
- Research Organization:
- Univ. of the Witwatersrand, Johannesburg
- OSTI ID:
- 6572834
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 233:4; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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Tue Dec 31 23:00:00 EST 1974
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Thu Oct 01 00:00:00 EDT 1981
· J. Neurosurg.; (United States)
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OSTI ID:5449389
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ANIMALS
APES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DRUGS
EVEN-ODD NUCLEI
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEASURING METHODS
NERVOUS SYSTEM
NORADRENALINE
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
STEROID HORMONES
SYMPATHOMIMETICS
VERTEBRATES
XENON 133
XENON ISOTOPES
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ANIMALS
APES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DRUGS
EVEN-ODD NUCLEI
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEASURING METHODS
NERVOUS SYSTEM
NORADRENALINE
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
STEROID HORMONES
SYMPATHOMIMETICS
VERTEBRATES
XENON 133
XENON ISOTOPES