Effect of subarachnoid hemorrhage on contractile responses and noradrenaline release evoked in cat cerebral arteries by histamine

Journal Article · Thu Oct 01 04:00:00 EDT 1981 · J. Neurosurg.; (United States)

DOI:https://doi.org/10.3171/jns.1981.55.4.0543· OSTI ID:5449389

Lobato, R D; Marin, J; Salaices, M; Rico, M L; Sanchez, C F

This study analyzes the changes induced by subarachnoid hemorrhage (SAH) on the contractile responses and the noradrenaline release evoked in cat cerebral arteries by histamine. The dose-dependent vasoconstriction induced by histamine on the cerebral arteries of normal cats was significantly reduced by diphenhydramine and phentolamine. When SAH was produced 3 and 7 days before the experiment, the histamine-induced vasoconstriction also decreased. Thereafter, a tendency to normalization in the contractile vascular responses was observed such that in 15 days after the hemorrhage it was not significantly different from that found in controls animals. The decrease in the contractile responses to histamine provoked by SAH was similar to that seen after pretreatment with intracisternal injections of 6-hydroxydopamine. The amount of radioactivity released by histamine following preincubation with /sup 3/H-noradrenaline from the cerebral arteries of cats exposed to SAH 3, 7, and 15 days before the experiment was significantly reduced when compared with controls. Moreover, the basal level of tritium release and the radioactivity retained at the end of the experiment were also decreased after SAH. Results indicate histamine releases noradrenaline from cat cerebral arteries, and SAH produce a transient denervation of the perivascular adrenergic nerve endings, which explained by the impairment of the indirect adrenergic mechanism involved in the overall contractile response elicited by this amine in cerebral arteries. Histamine does not seem to play a significant role in the production of the cerebral vasospasm occurring after SAH.

• OSTI ID: 5449389
• Journal Information: J. Neurosurg.; (United States), Journal Name: J. Neurosurg.; (United States) Vol. 55:4; ISSN JONSA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
AMINES
ANIMALS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
AZOLES
BIOCHEMICAL REACTION KINETICS
BLOOD VESSELS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CATS
CENTRAL NERVOUS SYSTEM
CEREBRUM
DRUGS
HEMORRHAGE
HETEROCYCLIC COMPOUNDS
HISTAMINE
HORMONES
IMIDAZOLES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
REACTION KINETICS
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
TRITIUM COMPOUNDS
VASOCONSTRICTION
VERTEBRATES